If you're thinking that this is no different to listening to the switchable tones in Rocksmith, let me highlight some advantages that I've found: NOTE: I'm constantly making little tweaks to this guide, so leave comments or suggestions for improvements. While this guide assumes use of the game on a PC or Mac, a similar setup should work perfectly well on an XBox or PS3 platform. Some newer guitar amplifiers, like the Line6 Amplifi or the Blackstar ID:Core series actually have full range speakers. Most guitar amplifiers are designed to clip frequencies outside of a certain range, so playing music audio through a guitar amp will never sound as good as through an FRFR speaker. This allows you to combine your guitar output with the music output from the game through a speaker that will give you the full frequency range of audio available.
If, like me, you have one, use a Full Range Flat Response (FRFR) PA speaker as your main audio output. This guide attempts to describe some options for using a guitar or bass amplifier, an effects chain (or multieffects pedal), and optionally, a PA or powered speaker system in combination with Rocksmith.